The clue "Sistine Chapel setting" last appeared in the New York Times crossword on May 21, 2016. The correct answer for this puzzle is "EDEN", a 4-letter word.
Solution EDEN is 4 letters long. So far we haven´t got a solution of the same word length.
There is 1 solutions. The longest is EDEN with 4 letters, and the shortest is EDEN with 4 letters.
No, "SISTINE CHAPEL SETTING" hasn´t seen a spike right now. Solvers are most interested in: Composition, Smudge, asexual, COMING into being and ANNOYING KID.
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The solution is 4 letters long.