The clue "Substance in tobacco" last appeared in the The Times Concise crossword on March 31, 2018. The correct answer for this puzzle is "NICOTINE", a 8-letter word.
Solution NICOTINE is 8 letters long. So far we haven´t got a solution of the same word length.
There is 1 solutions. The longest is NICOTINE with 8 letters, and the shortest is NICOTINE with 8 letters.
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The solution is 8 letters long.