The clue "Tissue layer" last appeared in the LA Times crossword on December 5, 2022. The correct answer for this puzzle is "PLY", a 3-letter word.
Solution PLY is our most searched for solution by our visitors. Solution PLY is 3 letters long. We have 0 further solutions of the same word length.
There are 2 solutions. The longest is MEMBRANE with 8 letters, and the shortest is PLY with 3 letters.
Indeed, "TISSUE LAYER" is among today´s most searched crossword clues (latest update: 21 Dec 2025). Many solvers are struggling with this one!
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Solutions are between 3 and 8 letters long.